FREMGANGSMAATE VED FREMSTILLING AV SVOVELHOLDIGE BENZIMIDAZOLDERIVATER

• Main Authors: GOENCZI, CSABA, SZVOBODA, GYOERGYNE, KELEMEN, ANDRAS, KISS, PAL, KOERMOECZI, GYOERGY, SZOMOR, TIBORNE, CSER, GABORNE, PALOSI, ENDRE, HEJA, GERGELY, KORBONITS, DEZSO
• Format: Patent
• Language: Norwegian
• Published: 13.11.1978
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; AGRICULTURE; ANIMAL HUSBANDRY; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FISHING; FORESTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

A process for the preparation of anthelmintic compounds of the formula: wherein R1 is hydrogen or -COOR; R5 is C1 to C4 alkyl; R2 is halogen, alkyl, trifluoromethyl, alkoxy, aryloxy, or aralkoxy; and R4 is hydrogen, alkyl, cycloalkyl; alkenyl, alkynyl or aralkyl; or pharmaceutically acceptable salts thereof comprises subjecting a bis compound of the formula: to reduction to cleave the disulfide linkage and where R4 is other then hydrogen, subsequent reaction of the mercapto group. Intermediate compounds and a process for preparing same are also disclosed.