2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-oner, fremgangsmåte for fremstilling derav og farmasøytiske preparater inneholdende slike

• Main Authors: Antonios-McCrea, William, Brinner, Kristin, Brammeier, Nathan, Pick, Teresa E, Tulinsky, John, Gao, Zhenhai, Renhowe, Paul A, Lin, Xiaodong, Shafer, Cynthia M, Machajewski, Timothy D, Xia, Yi, Doughan, Brandon M, Rico, Alice, McBride, Christopher, McKenna, Maureen, Costales, Abran, Gong, Baoqing, Barsanti, Paul A, Gu, Dan, Dolan, John, Zhou, Yasheen, Wang, X Michael, Levine, Barry H, Mendenhall, Kris, Poon, Daniel J
• Format: Patent
• Language: Norwegian
• Published: 30.04.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Det beskrives 2-arnino-7,8-dihydro-6H-pyrido[4,3-d]pyrirnidin-5-on forbindelser, deres stereoisomerer, tautomerer, farmasøytisk akseptable salter og prodrugs derav; preparater som inkluderer en farmasøytisk akseptabel bærer og en eller flere av 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-on forbindelsene, enten alene eller i kombinasjon med minst et ytterligere terapeutisk middel. Det beskrives videre metoder for anvendelse av 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-on forbindelser, enten alene eller i kombinasjon med minst et ytterligere terapeutisk middel, for profylakse eller behandling av cellulære proliferative, virale, autoimmune, kardiovaskulære og sentralnervesystem sykdommer. Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.