Forbindelser med HIV-proteaseaktivitet, farmasøytisk preparat derav og anvendelse derav ved fremstillingen av et medikament for behandling eller forebyggelse av symptomene eller virkningene av HIV-infeksjon

• Main Authors: YU RICHARD H, DASTGAH AZAR, ZHANG JIANCUM, YANG ZHENG-YU, LEE WILLIAM A, ARIMILLI MURTY N, XU LIANHONG, CHEN JAMES M, TARIO JAMES D, BRYANT CLIFFORD M, PYUN HYUNG-JUNG, MACKMAN RICHARD L, HE GONG-XIN, WANG JIANYING, FARDIS MARIA, SWAMINATHAN SUNDARAMOORTHI, BECKER MARK M, WILLIAMS MATTHEW A, NELSON PETER HAROLD, LIU HONGTAO, MITCHELL MICHAEL L, JIN HAOLUN, ZHANG LIJUN, LIN KUEI-YING, KIM CHOUNG U, CHEN XIAOWU, ROWE TANISHA D, LEE CHRISTOPHER P, SPARACINO MARK L
• Format: Patent
• Language: Norwegian
• Published: 31.08.2015
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; TESTING; VINEGAR; WINE

Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.