Vannopploselige fenylpyridazinderivater medisiner inneholdende disse, samt anvendelse av disse for fremstilling av medikamenter for behandling av sykdom

Compounds having the formula (1): wherein R represents an alkyl or alkenyl group, R and R each independently represents a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R and R may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted,...

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Main Authors KOSHI TOMOYUKI, SHIGYO HIROMICHI, SATO SEIICHI, KYOTANI YOSHINORI, YASUOKA KYOKO, TAKEMURA SHUNJI, YOSHIZAKI HIDEO, TOTSUKA JUNKO, KITAMURA TAKAHIRO
Format Patent
LanguageNorwegian
Published 29.06.2009
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds having the formula (1): wherein R represents an alkyl or alkenyl group, R and R each independently represents a hydrogen atom or an alkyl, hydroxyalkyl, dihydroxyalkyl or alkynyl group, or R and R may be fused together with the adjacent nitrogen atom to form a substituted or unsubstituted, nitrogen-containing, saturated heterocyclic group, X, Y and Z each independently represents a hydrogen atom, an alkyl group, a halogen atom or the like, and n stands for an integer of from 1 to 5; and also to pharmaceutical compositions containing them. These compounds have inhibitory activity against IL-1 beta production, high water solubility and good oral absorbability.
Bibliography:Application Number: NO20040001250