Kondenserte polycykliske heterosyklusderivater, fremstilling og anvendelse av slike forbindelser, samt preparater og midler omfattende slike forbindelser

• Main Authors: YAMAGUCHI ATSUMI, NAKAMURA KATSUJI, YOSHINO HIROSHI, KOYANAGI NOZOMU, UENAKA TOSHIMITSU, KOTAKE YOSHIHIKO, SUGUMI HIROYUKI, OKADA TOSHIMI, KAMATA JUN-ICHI, NIIJIMA JUN, YOSHIMATSU KENTARO, KITO KYOSUKE, NAGASU TAKESHI
• Format: Patent
• Language: Norwegian
• Published: 28.05.2001
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Novel fused polycyclic heterocycle derivatives having excellent antitumor effects and a process for producing the same. A compound represented by the following general formula (I) or pharmacologically acceptable salts thereof: wherein the ring A represents an optionally substituted monocyclic aromatic ring or a dicyclic fused ring in which at least one of the rings is an aromatic ring; the ring B represents pyrrole, 4H-1,4-oxazine, 4H-1,4-thiazine or 4(1H)-pyridone; the ring C represents an optionally substituted, monocyclic or dicyclic fused aromatic ring; and Y represents a group represented by the formula -e-f (wherein e represents a lower alkylene; and f represents amidino, guanidino or amino optionally substituted by optionally hydroxylated or optionally lower-alkylaminated lower alkyl; provided that the cases where the rings A and B are both optionally substituted monocyclic aromatic rings are excluded. Which has an excellent antitumor activity.