Aprotininanaloger

Aprotinin analogues (I) with reduced nephrotoxicity and with a reduced position net charge, provided as follows, are claimed: (1) at least one positively charged aminoacid residue outside the protease binding site is removed or replaced with a neutral or negatively charged aminoacid residue; and/or...

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Bibliographic Details
Main Authors DINESS, VIGGO, BJOERN, SOEREN ERIK, NOERSKOV-LAURITSEN, LEIF, NORRIS, KJELD, CHRISTENSEN, NIELS DYHR, BREGENGAARD, CLAUS
Format Patent
LanguageNorwegian
Published 12.02.2001
Edition5
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:Aprotinin analogues (I) with reduced nephrotoxicity and with a reduced position net charge, provided as follows, are claimed: (1) at least one positively charged aminoacid residue outside the protease binding site is removed or replaced with a neutral or negatively charged aminoacid residue; and/or (2) at least one negatively charged aminoacid residue is inserted or added; and/or (3) at least one neutral aminoacid residue is replaced with a negatively charged aminoacid residue; and/or (4) to provide reduced stability, one or more aminoacid residues are deleted, added or replaced with one or more other aminoacid residues.
Bibliography:Application Number: NO19930001220