FremgangsmÕte og mellomprodukter for fremstilling av naftyridonkarboksylsyresalter

This invention relates to novel processes for preparing compounds of formula (I), wherein R H is as defined below, which is a salt of the naphthyridone antibiotic 7-(1 alpha ,5 alpha ,6 alpha )-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-...

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Bibliographic Details
Main Authors BRAISH, TAMIM F, FOX, DARRELL EUGENE, NORRIS, TIMOTHY, ROSE, PETER R
Format Patent
LanguageNorwegian
Published 02.08.1999
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This invention relates to novel processes for preparing compounds of formula (I), wherein R H is as defined below, which is a salt of the naphthyridone antibiotic 7-(1 alpha ,5 alpha ,6 alpha )-(6-amino-3-azabicyclo[3.1.0]hex-3-yl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carbocylic acid and a pharmaceutically acceptable acid. The salt and antibiotics have antibacterial activity. This invention also relates to novel intermediates, and processes for their preparation, of formulae (IV), (IIIB) or (IIIA). The compounds of formulae (IIIA), (IIIB) and (IV) are useful as intermediates in the syntheses of the azabicyclo naphthyridone carboxylic acid alkanesulfonic acid salts of formula (I).
Bibliography:Application Number: NO19960002990