Aminokinolonderivater samt middel mot HIV

• Main Authors: KATSUBE, TETSUSHI, KIMURA, TOMIO
• Format: Patent
• Language: Norwegian
• Published: 22.02.1999
• Edition: 5
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Compounds of formula (Ia), (Ib) or (Ic): in which: X is H or halogen; Y is H, halogen, alkyl, or optionally substituted amino; Z is COOH or 5-tetrazolyl; Q is N or C having a substituent R , and R is H, halogen, or optionally substituted alkoxy or alkyl; W is O or S; T is optionally substituted alkylene or alkenylene; R is H, alkenyl, alkynyl, amino, cycloalkyl, alkoxy, aryl, an aromatic heteromonocycle, a fused aromatic group or alkyl, said groups, other than H, optionally being substituted; or R and R may together represent a group of formula (f): wherein A is H or optionally substituted alkyl; G is N or =CH; G is methylene, =CO, O, S or optionally substituted amino; and p = 0 or 1; R represents a group of formula (h) or (i): where R and R are optionally substituted and each is aryl, an aromatic heteromonocyclic group, or a fused aromatic group; R , R and R are each H or alkyl; R is H, alkyl, -OH or alkoxy; n and n' are each 1 or 2; m = 0 or 1 and n'' = 1, 2, 3 or 4; and pharmaceutically acceptable salts and esters thereof, have useful anti-HIV activity, and can be used in therapy.