STAT3/5 activeringsinhibitor

• Main Authors: AKAMATSU SEIJI, HAYASHI KAZUHIKO, SUGIYAMA KAZUHISA, YANAGIHARA YASUO, OKUNO MITSUHIRO, YOSHIDA KENJI, WATANABE TAKASHI, KODAMA TAKESHI, OHNISHI KENJI, OHI NAOTO, SUMIDA TAKUMI, OHBUCHI YUTAKA, TANAKA HIDEO, MOTOYAMA MASAAKI, SUZUKI TAKASHI, SEKIGUCHI KAZUO, KIYONO KUNIHIKO
• Format: Patent
• Language: Norwegian
• Published: 27.03.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Et formål med foreliggende oppfinnelse er å tilveiebringe en STAT3/5 aktiveringsinhibitor. Foreliggende oppfinnelse tilveiebringer en STAT3/5 aktiveringsinhibitor inneholdende en aromatisk forbindelse representert ved den generelle formel eller et salt derav som en aktiv bestanddel: hvor X1 representerer et nitrogenatom eller en gruppe -CH=, R1 representerer en gruppe -Z-R6, hvor Z representerer en gruppe -CO-, en gruppe -CH(OH)- eller lignende, R6 representerer en 5-til 15-leddet monocyklisk, dicyklisk eller tricyklisk mettet eller umettet heterocyklisk gruppe som har 1 til 4 nitrogenatomer, oksygenatomer eller svovelatomer, R2 representerer et hydrogenatom eller et halogenatom, Y representerer en gruppe -O-, en gruppe -CO-, en gruppe -CH(OH)-eller en lavere alkylengruppe og A representerer en gruppe hvor R3 representerer et hydrogenatom, en lavere alkoksygruppe eller lignende, p representerer 1 eller 2, R4 representerer en imidazolyl lavere alkylgruppe eller lignende. 1 An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X 1 represents a nitrogen atom or a group -CH=, R 1 represents a group -Z-R 6 , in which Z represents a group -CO-, a group -CH(OH)- or the like, R 6 represents a 5-to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R 2 represents a hydrogen atom or a halogen atom, Y represents a group -O-, a group -CO-, a group -CH(OH)- or a lower alkylene group, and A represents a group wherein R 3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R 4 represents an imidazolyl lower alkyl group or the like.