Hoyaffinitets humane og humaniserte anti-alfa5 beta1-integrin funksjonsblokkerende antistoffer med redusert immunogenisitet

• Main Authors: WILLUDA JORG, BOSSLET KLAUS, PRASSLER JOSEF, PETRUL HEIKE, MENRAD ANDREAS, ZOPF DIETER, STEIDL STEFAN, PETIT-FRERE CORINNE
• Format: Patent
• Language: Norwegian
• Published: 23.02.2009
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

Sammendrag Den foreliggende oppfinnelse vedrører rekombinante, humane eller humaniserte polypeptider som binder a5ß1-integrin med høy affinitet og blokkerende funksjon. Videre er diagnostiske og farmasøytiske anvendelser av polypeptidene beskrevet. The present invention relates to recombinant human or humanized polypeptides which bind to alpha5beta1 integrin with high affinity and blocking function. Further, diagnostic and pharmaceutic applications of the potypeptides are disclosed.