Diaryleterderivater som antitumor midler

• Main Authors: SAKAMOTO MAKOTO, MIYAJIMA KEISUKE, YAMADA SATOSHI, MATSUYAMA HIRONORI, KOJIMA YUTAKA, YASUMURA KOICHI, HIGUCHI KUMI, KODAMA TAKESHI, OHNISHI KENJI, OTSUJI SHUN, NAKAGAWA TAKASHI, SUMIDA TAKUMI, MOTOYAMA MASAAKI, KAN KEIZO, TAKASU HIDEKI
• Format: Patent
• Language: Norwegian
• Published: 13.08.2008
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Et formål med foreliggende oppfinnelse er å tilveiebringe et medisinsk medikament sterkt forbedret i anti-tumor-aktivitet og utmerket i sikkerhet. Ifølge foreliggende oppfinnelse tilveiebringes et medisinsk medikament inneholdende en forbindelse representert ved den følgende generelle formel (1) eller et salt derav som en aktiv bestanddel: [Formel 1] hvor X1 representerer et nitrogenatom eller en gruppe -CH=, R1 representerer en gruppe -Z-R6, hvor Z representerer en gruppe -CO-, en gruppe -CH(OH)- eller lignende, R6 representerer en 5- til 15-leddet monocyklisk, dicyklisk eller tricyklisk mettet eller umettet heterocyklisk gruppe som har 1 til 4 nitrogenatomer, oksygenatomer eller svovelatomer, R2 representerer et hydrogenatom eller et halogenatom, Y representerer en gruppe -O-, en gruppe -CO-, en gruppe -CH(OH)- eller en lavere alkylengruppe og A representerer [Formel 2] hvor R3 representerer et hydrogenatom, en lavere alkoksygruppe eller lignende, p representerer 1 eller 2, R4 representerer en imidazolyl-lavere alkylgruppe eller lignende. An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group -CH , R1 represents a group -Z-R6, in which Z represents a group -CO-, a group -CH(OH)- or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group -O-, a group -CO-, a group -CH(OH)- or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.