4- (4-Brom-2-Fluoranilino) -6-Metoksy-7- (1-Metylpiperidin-4 -Ylmetoksy) kinazolinmonohydrate

• Main Authors: PATEL ZAKARIYA, BOOTH REBECCA JANE, MEYRICK BRIAN ROGER, STOREY RICHARD ANTHONY
• Format: Patent
• Language: Norwegian
• Published: 27.06.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Foreliggende oppfinnelse angår et ZD6474 monohydrat, fremgangsmåter for fremstilling av et ZD6474 monohydrat, farmasøytiske preparater omfattende et ZD6474 monohydrat som den aktive bestanddel, anvendelse av et ZD6474 monohydrat ved fremstilling av medikamenter for anvendelse for produksjon av antiangiogene og/eller vaskulære permeabilitets-reduserende effekter hos varmblodige dyr så som mennesker og anvendelse av et ZD6474 monohydrat ved metoder for behandling av sykdomstilstander forbundet med angiogenese og/eller øket vaskulær permeabilitet, så som kreft, hos varmblodige dyr så som mennesker. The present invention relates to a ZD6474 monohydrate, to processes for the preparation of a ZD6474 monohydrate, to pharmaceutical compositions comprising a ZD6474 monohydrate as the active ingredient, to the use of a ZD6474 monohydrate in the manufacture of medicaments for use in the production of antiangiogenic and/or vascular permeability reducing effects in warm-blooded animals such as humans, and to the use of a ZD6474 monohydrate in methods for the treatment of disease states associated with angiogenesis and/or increased vascular permeability, such as cancer, in warm-blooded animals such as humans.