Syklisk aminderivat eller salt av dette

• Main Authors: OHMORI JUNYA, KAWABATA SHIGEKI, YAMASAKI SHINGO, HAYASHIBE SATOSHI, MAENO KYOICHI, SUZUKI JOTAROU, KANAYAMA TAKATOSHI, SHITAKA YOSHITSUGU, HOSHII HIROAKI, TOBE TAKAHIKO, SHIRAISHI NOBUYUKI, SUZUKI DAISUKE
• Format: Patent
• Language: Norwegian
• Published: 23.05.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Forbindelse som er anvendelig som en NMDA-antagonist og med et bredt sikkerhetsområde, som er et terapeutisk middel for Alzheimers sykdom, vaskulær demens (vaskulær agnosi), Parkinsons sykdom, iskemisk apopleksi og smerte, eller et preventivt middel for disse. Forbindelsen er et aminderivat eller et salt av dette, omfattende en aminholdig struktur (A) og en di- eller tri-syklisk, kondensert ring (indan, tetra-lon, 4,5,6,7-tetrahydrobenzotiofen, 4,5,6,7-tetrahydrobenzofuran, 7,8-di-hydro-6H-indeno[4,5-b]furan, 2,3-di-hydro-lH-syklopenta[a]naftalen etc.) bundet til strukturen (A) via X1 (binding, lavere alkylen etc). NMDA-antagonisten inneholder derivatet eller saltet som en aktiv ingrediens. Provided are compounds which are an NMDA antagonist having a broad safety margin and are useful as a treating agent or a preventing agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, pain, etc. Concretely provided are an amine derivative or its salt characterized in that the amine-containing structure A therein bonds to a 2- or 3-cyclic condensed ring (e.g., indane, tetralone, 4,5,6,7-tetrahydrobenzothiophene, 4,5,6,7-tetrahydrobenzofuran, 7,8-dihydro-6H-indeno[4,5-b]furan, 2,3-dihydro-1H-cyclopenta[1]naphthalene) via X 1 (bond or lower alkylene); and an NMDA antagonist containing it as an active ingredient thereof.