5-substituerte 2-fenylaminobenzamider som MEK-inhibitorer

An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically accepta...

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Bibliographic Details
Main Authors Iikura, Hitoshi, Kohchi, Masami, Kohchi, Yasunori, Tsujii, Shinji, Aida, Satoshi, Shimma, Nobuo, Murata, Takeshi, Matsubara, Yasuaki, Miwa, Masanori, Aso, Kosuke, Isshiki, Yoshiaki, Mizuguchi, Eisaku
Format Patent
LanguageNorwegian
Published 19.04.2007
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:An objective of the present invention is to provide compounds that exhibit strong MEK-inhibiting activity and are stable in vivo and soluble in water, which can be used as preventive or therapeutic agents for proliferative diseases. The compounds of the present invention and pharmaceutically acceptable salts thereof are represented by the following formula (1): [where R 1 , R 2 , R 3 , R 4 , and X are the same as defined in the present patent application].
Bibliography:Application Number: NO20070001042