Nye tricykliske azepinforbindelser, fremgangsmater for deres fremstilling og farmasoytiske sammensetninger inneholdende dem

• Main Authors: RENARD PIERRE, CARATO PASCAL, PIERRE ALAIN, BERTHELOT PASCAL, PFEIFFER BRUNO, GALLET SEBASTIAN, HICKMAN JOHN, LEBEGUE NICOLAS, FLOUQUET NATHALIE
• Format: Patent
• Language: Norwegian
• Published: 02.09.2005
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Forbindelser med formel (I): hvori: ? ring A representerer en benzo- eller pyridogruppe eventuelt kondensert i 2-3-, 3-4-eller 4-5-stillingen og eventuelt substituert, ? W representerer en gruppe X-Y eller Y-X hvori: X representerer en gruppe SO2 eller C=O, og Y representerer et oksygenatom eller en gruppe N-R3, ? n representerer null eller et heltall hvori 1 = n = 6, ? G, Ri, R2 og R3 er som definert i beskrivelsen, deres enantiomerer og diastereoisomerer, og addisjonssalter derav med en farmasøytisk akseptabel syre eller base. Medikamenter A compound of formula (I): wherein: represents benzo or pyrido, optionally fused in the 2-3, 3-4 or 4-5 position to a phenyl, (C4-C8)cycloalkyl or heterocyclic group, which may be optionally substituted, W represents X-Y or Y-X, wherein: X represents and Y represents oxygen or N-R3, n represents zero or an integer from 1 to 6, G, R1, R2 and R3 are as defined in the description, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful for the treatment of cancerous diseases.