ANALOGIFREMGANGSMAATE FOR FREMSTILLING AV TERAPEUTISK AKTIVE 4 (5)-SUBSTITUERTE IMIDAZOL-DERIVATER, OG MELLOMPRODUKTTIL BRUK VED FREMSTILLINGEN

The invention provides 4(5)-substituted imidazole derivatives of formula and their acid addition salts, in which either X is -CH2- and R1 is -CN, -COOH, COO(lower alkyl), -CHO, -CO (lower alkyl), lower alkyl of 3 to 5 carbon atoms, lower alkenyl, or lower (hydroxy alkyl) or X is -@@CH2R)-, -C(:CH-R)...

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Bibliographic Details
Main Authors KARJALAINEN, ARJA LEENA, KARJALAINEN, ARTO JOHANNES
Format Patent
LanguageNorwegian
Published 25.09.1991
Edition5
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides 4(5)-substituted imidazole derivatives of formula and their acid addition salts, in which either X is -CH2- and R1 is -CN, -COOH, COO(lower alkyl), -CHO, -CO (lower alkyl), lower alkyl of 3 to 5 carbon atoms, lower alkenyl, or lower (hydroxy alkyl) or X is -@@CH2R)-, -C(:CH-R)- or -CH(CH2R)-, where R is hydrogen or lower alkyl, and R1 is lower alkyl, and R3 and R4 are each hydrogen, methyl, ethyl, methoxy, or halogen, and novel intermediates and processes for their preparation. These compounds, in particular when R1 is lower alkyl, lower alkenyl, or lower (hydroxy alkyl), possess valuable pharmacological properties and are useful especially as selective alpha 2-receptor antagonists.
Bibliography:Application Number: NO19870002004