ANALOGIFREMGANGSMAATE FOR FREMSTILLING AV TERAPEUTISK AKTIVT 1-(4-AMIONFENYL)-4-METHYL-7,8-METHYLENDIOXY-3,4-DIHYDRO-5H-2,3-BENZODIAZEPIN

The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzo diazepi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. (I) The new compounds of formula (I) can be pr...

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Bibliographic Details
Main Authors LANG, ZSUZSA, BORSY, JOZSEF, ANDRASI, FERENC, ELEKES, ISTVAN, KOROESI, JENO, LANG, TIBOR, BOTKA, PETER, BERZSENYI, PAL, GOLDSCHMIDT, KATALIN, HAMORI, TAMAS
Format Patent
LanguageNorwegian
Published 23.07.1990
Edition5
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to new 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-3,4-dihydro-5H-2,3-benzo diazepi ne of formula (1), optically active isomers and acid addition salts thereof as well as to pharmaceutical compositions containing these compounds. (I) The new compounds of formula (I) can be prepared by reducing 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine of formula (II) with an inorganic or organic-inorganic and/or complex metal hydride and, if desired, separating the optically active forms of the compound of formula (I) thus-obtained and, if desired, converting the base or bases into acid addition salts or converting the salts into the free bases(s). (II) The new compound of formula (I) possesses significant central nervous effects and can advantageously be used in the therapy.
Bibliography:Application Number: NO19870003426