FREMGANGSM TE FOR FREMSTILLING AV AMINDERIVATER

Compounds of formula (II> in which R1 is C1-4 alkyl, preferably methyl, are prepared by reaction of a compound of formula (I> where Q is hydrogen or a cation derived from a suitable base with a suitable alkylating agent such as an alkyl halide or a dialkyl sulphate. The compound of formula (II...

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Bibliographic Details
Main Authors DANSEY, ROGER, SEAGER, JOHN FREDERICK
Format Patent
LanguageNorwegian
Published 25.09.1989
Edition4
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:Compounds of formula (II> in which R1 is C1-4 alkyl, preferably methyl, are prepared by reaction of a compound of formula (I> where Q is hydrogen or a cation derived from a suitable base with a suitable alkylating agent such as an alkyl halide or a dialkyl sulphate. The compound of formula (II) may be converted into a histamine H2-antagonist containing an -NHC(=CHNO2)NHCH3 end group, e.g. ranitidine, by reaction with an appropriate amine. The compound of formula (I) (compounds where Q is H or alkali metal are said to be novel) may be prepared by reaction of methyl isothiocyanate with the carbanion of nitromethane (preferably generated in situ by reaction of nitromethane with a suitable base) in the presence of dimethyl sulphoxide as solvent, Q representing the cation derived from the base used to produce the carbanion of nitromethane.
Bibliography:Application Number: NO19850002418