ANALOGIFREMGANGSMAATE VED FREMSTILLING AV NYE KINAZOLINDERIVATER

Quinazoline derivatives of formula: (I) wherein R represents: (1) a straight or branched chain unsaturated hydrocarbon group, or (2) a straight or branched chain saturated or unsaturated hydrocarbon group which is substituted by at least one: heteroatom, the or each heteroatom being halogeno when R...

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Bibliographic Details
Main Authors JONES, TERENCE RICHARD, CALVERT, ALAN HILARY, HARRAP, KENNETH REGINALD
Format Patent
LanguageNorwegian
Published 06.10.1986
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Quinazoline derivatives of formula: (I) wherein R represents: (1) a straight or branched chain unsaturated hydrocarbon group, or (2) a straight or branched chain saturated or unsaturated hydrocarbon group which is substituted by at least one: heteroatom, the or each heteroatom being halogeno when R is a C1 hydrocarbon group; or saturated carbocyclic group; or group containing at least one heteroatom, the or each heteroatom being O, N or S when R contains a cyclic group; and n is 0 or an integer of 1-4; X or, when n is an integer of at least 2, each X independently, represents a halogeno, C1-C4 alkyl, aryl or aralkyl group or a group including at least one heteroatom; and Y represents a group of formula: (a) (b) or (c) wherein m>/=1 (poly-L-glutamates); and the pharmaceutically acceptable salts and esters thereof, which are suitable as anti-cancer agents.
Bibliography:Application Number: NO19800003868