ANALOGIFREMGANGSMAATE FOR FREMSTILLING AV FARMAKOLOGISK AKTIVE 1-(N-(P-FLUORBENZOYLPROPYL)-4-PIPERIDYL)-IMIDAZOLIDINON-DERIVATER

Novel 1-[N-(p-fluorobenzoylpropyl)-4-piperidyl]ureas of the formula I below, in which R is a hydrogen atom, an acetyl group, an alkyl group with 1 to 3 carbon atoms or the phenyl group, are prepared by reacting a correspondingly substituted N-(4-piperidyl)-2-imidazolidinone with a p-fluorobutyrophen...

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Bibliographic Details
Main Authors WALTHER, GERHARD, LANGBEIN, ADOLF, DANNEBERG, PETER, KUHN, FRANZ JOSEF
Format Patent
LanguageNorwegian
Published 06.08.1980
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Novel 1-[N-(p-fluorobenzoylpropyl)-4-piperidyl]ureas of the formula I below, in which R is a hydrogen atom, an acetyl group, an alkyl group with 1 to 3 carbon atoms or the phenyl group, are prepared by reacting a correspondingly substituted N-(4-piperidyl)-2-imidazolidinone with a p-fluorobutyrophenone which has in the omega position a group which can be eliminated under the reaction conditions. The products of the process can be converted into their physiologically tolerated acid addition salts. It is additionally possible for resulting compounds of the formula I in which R is hydrogen to be acetylated by reaction with acetyl chloride or acetic anhydride. The novel compounds show the typical range of effects of the neuroleptics and can therefore be employed as CNS-depressant agents, sedatives and tranquillizers.
Bibliography:Application Number: NO19750001725