ANALOGIFREMGANGSMAATE FOR FREMSTILLING AV TERAPEUTISK AKTIVE BENZOMORFANER

Novel 2-tetrahydrofurfuryl-6-7-benzomorphans of the accompanying formula I, in which R denotes methyl, ethyl or propyl; R denotes hydrogen, methyl or ethyl; R denotes hydrogen or methyl; and R denotes hydrogen, alkyl having 1 to 4 carbon atoms or acyl having 2 to 5 carbon atoms, are prepared by intr...

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Bibliographic Details
Main Authors WALTHER, GERHARD, STOCKHAUS, KLAUS, MERZ, HERBERT, LANGBEIN, ADOLF
Format Patent
LanguageNorwegian
Published 04.02.1980
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Novel 2-tetrahydrofurfuryl-6-7-benzomorphans of the accompanying formula I, in which R denotes methyl, ethyl or propyl; R denotes hydrogen, methyl or ethyl; R denotes hydrogen or methyl; and R denotes hydrogen, alkyl having 1 to 4 carbon atoms or acyl having 2 to 5 carbon atoms, are prepared by introducing the tetrahydrofurfuryl radical into appropriately substituted norbenzomorphans by the methods of N-alkylation. The resulting bases of the formula I can then be converted into their acid addition salts. The compounds of the formula I and their acid addition salts are distinguished by a therapeutically utilisable action on the central nervous system. Particularly to be emphasised is their analgesic action, which frequently exceeds that of morphine, without exhibiting the undesired side effects of morphine, e.g. the addictive action.
Bibliography:Application Number: NO19750000773