NO135785B

Title compds. of formula (I): where R is H or (1-4C) alkyl, and R1 is H, (1-4C) alkyl or -(CH2)nNR2R3 where n is 1 or 2 and R2 and R3 are H or (1-4C) alkyl, and salts of (I) (R1 = H or (CH2)nNR2R3), are anti-inflammatories and analgesics. Cpds. are rpepd. by condensing (a) o-cyanobenzylbromide (III)...

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Bibliographic Details
Main Authors BIASOLI G, LOGEMANN W, BUTTINONI A, GIRALDI P N, NANNINI G, TOMMASINI R
Format Patent
LanguageEnglish
Published 21.02.1977
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Title compds. of formula (I): where R is H or (1-4C) alkyl, and R1 is H, (1-4C) alkyl or -(CH2)nNR2R3 where n is 1 or 2 and R2 and R3 are H or (1-4C) alkyl, and salts of (I) (R1 = H or (CH2)nNR2R3), are anti-inflammatories and analgesics. Cpds. are rpepd. by condensing (a) o-cyanobenzylbromide (III) with a p-aminophenylacetonitrile or a p-aminophenylacetic acid ethyl ester (IV), (b) phthalide, thiophthalide or phthalaldehyde with (IV), (c) phthalic anhydride or a phthalic acid, Me or Et ester with (IV) followed by partial reduction of the intermediate, and in each case (a, b and c) hydrolysing with strong acid or base to (I) (R1 = H) and (opt.) esterifying.
Bibliography:Application Number: NO19710004082