Preparation method and application of novel artemisinin derivatives and liposomes

Disclosed is a preparation method and application of the novel artemisinin derivative and its 5 liposomes. The method comprises the following steps: firstly, synthesizing artemisinin derivative (TPP-SS-ATS) which is sensitive to glutathione (GSH) and has mitochondrial targeting function; then the no...

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Bibliographic Details
Main Authors SHENGNAN SHEN, CHONG QIU, DANDAN LIU, LIWEI GU, SHUO SHEN, JUNZHE ZHANG, MAOBO DU, SHUZHI LIU, JIGANG WANG
Format Patent
LanguageEnglish
Published 19.01.2024
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:Disclosed is a preparation method and application of the novel artemisinin derivative and its 5 liposomes. The method comprises the following steps: firstly, synthesizing artemisinin derivative (TPP-SS-ATS) which is sensitive to glutathione (GSH) and has mitochondrial targeting function; then the novel artemisinin derivative liposomes (TPP-SS-ATS-LS) were prepared by film dispersion method. The novel artemisinin derivative liposomes (TPP-SS-ATS-LS) prepared by the invention can realize dual-target drug delivery to tumour tissues and tumour cell mitochondria, 10 and remarkably improve the anti-tumour efficacy of artemisinin drugs.
Bibliography:Application Number: NL20232035226