Means and methods for multiparameter cytometry-based leukocyte subsetting

The invention relates to the field of diagnostic immunology. Provided are means and methods for multiparameter cytometry-based leukocyte subsetting, which is advantageously used for the monitoring of the immune status of a subject, and/or for monitoring the effects of an immune modulatory treatment....

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Main Authors JOSÉ ALBERTO ORFAO DE MATOS CORREIA E VALE, ANNIECK MARGO DIKS, JACOBUS JOHANNES MARIA VAN DONGEN, ALEJANDRO HERNÁNDEZ DELGADO, ELENA BLANCO ÁLVAREZ, MAGDALENA AGNIESZKA BERKOWSKA, VITOR DESSANTI BOTAFOGO GONCALVES, DANIELA PINTO DAMASCENO, KYRA VAN DER PAN, MARTÍN PÉREZ Y ANDRÉS, CRISTINA ISABEL GONÇALVES GRUNHO TEODÓSIO, WOUTER BERNARD LOUIS VAN DEN BOSSCHE, JULIA MARIA ALMEIDA PARRA
Format Patent
LanguageEnglish
Published 20.07.2021
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:The invention relates to the field of diagnostic immunology. Provided are means and methods for multiparameter cytometry-based leukocyte subsetting, which is advantageously used for the monitoring of the immune status of a subject, and/or for monitoring the effects of an immune modulatory treatment. Provided among others is a reagent composition comprising antibodies conjugated to a detectable label, the conjugated antibodies being directed against the following combination of markers: CD141, HLA-DR, CD16, CD33, CD300e, CD303 and CD14, wherein the antibodies directed against CD300e and CD303 may be conjugated to the same label.
Bibliography:Application Number: NL20192024163