INHIBIDORES DE LA METALOPROTEINASA MATRIZ

• Main Authors: KHERA MANOJ KUMAR, SRIVASTAVA PUNIT KUMAR, MUSIB ARPITA, REDDY RANADHEER, TIWARI MANOJ KUMAR, SONI AJAY, SATTIGERI VISWAJANANI, PALLE VENKATA P, JOSEPH SONY, RAUF ABDUL REHMAN ABDUL, DASTIDAR SUNANDA G
• Format: Patent
• Language: Spanish
• Published: 06.04.2011
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

La presente invención se trata de B-Hidroxy y amino sustituido por acidos carboxilicos, los cuales actuan en los inhibidores meteloproteinasas de la matriz, particularmente diasteorometicamente puro acido B-hidroxy carboxilico, correspondiendo procesos de la síntesis de y composiciones farmacéuticas conteniendo los compuestos de la presente invención. Los compuestos de la presente invención son útiles en el tratamiento de varias enfermedades inflamatorias, autoinmunológicas, y alérgicas, como método de tratamiento de asma, artritis reumatoide, COPD, renitis, Osteo artritis, artritis soriatica, soriasis, fibrosis pulmonar, desordenes de saneamiento de heridas, inflamaciones pulmonares, Síndrome de desorden respiratorio, perodontitis, esclerosis múltiple, gingivitis, ateroesclerosis, proliferación neointimal, la cual conlleva a fallas del corazón reostenosis y eschemica, paros cardíacos, enfermedades renales, metasis de tumores, y otros desordenes inflamatorios caracterizados por la sobre expresión y sobre activación de la metaloproteinas de la matriz usando compuestos. The present invention relates to ²-hydroxy and amino substituted carboxylic acids, which act as matrix metalloprotease inhibitors, particularly diastereomerically pure ²-hydroxy carboxylic acids, corresponding processes for the synthesis of and pharmaceutical compositions containing the compounds of the present invention. Compounds of the present invention are useful in the treatment of various inflammatory, autoimmune and allergic diseases, such as methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, wound healing disorders, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, neointimal proliferation, which leads to restenosis and ischemic heart failure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by the over-expression and over-activation of a matrix metalloproteinase using the compounds.