GREMLIN-1 CRYSTAL STRUCTURE AND INHIBITORY ANTIBODY

This invention relates to crystals of the human Gremlin-I protein, and the human Gremlin-I protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-I (on its own, or in complex with the antibody) and uses of these structures in screening for agents...

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Bibliographic Details
Main Authors TWOMEY, Breda, MCMILLAN, David James, DAVIES, Gareth Charles Glyndwr, WRIGHT, Michael John, DEDI, Neesha
Format Patent
LanguageEnglish
Published 25.04.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TESTING
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Summary:This invention relates to crystals of the human Gremlin-I protein, and the human Gremlin-I protein in complex with an inhibitory antibody. The invention also relates to the structure of human Gremlin-I (on its own, or in complex with the antibody) and uses of these structures in screening for agents which modulate Gremlin-I activity. The invention further provides antibodies which bind an allosteric inhibitory site on Gremlin-I, together with pharmaceutical compositions and medical uses of such antibodies and agents identified by the screening methods.
Bibliography:Application Number: MY2019PI03411