IMIDAZODIAZEPINE COMPOUND

[Problem] Provided is a compound which is useful as a dopamine DI receptor positive allosteric modulator (DI PAM). [Means for Solution] The present inventors have studied a compound which has a positive allosteric modulating action (PAM action) on a dopamine DI receptor and which can be used as an a...

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Bibliographic Details
Main Authors MASATAKA MORITA, SHIMPEI KAWAKAMI, SHIGEKI KUNIKAWA, JUNKO YARIMIZU, TOMOYOSHI IMAIZUMI, NAOYUKI MASUDA
Format Patent
LanguageEnglish
Published 19.06.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:[Problem] Provided is a compound which is useful as a dopamine DI receptor positive allosteric modulator (DI PAM). [Means for Solution] The present inventors have studied a compound which has a positive allosteric modulating action (PAM action) on a dopamine DI receptor and which can be used as an active ingredient of a pharmaceutical composition for preventing and/or treating cognitive impairment, schizophrenia negative symptom, CIAS, Parkinson's disease, Alzheimer's disease, Huntington's disease, depression, ADHD, drug dependency, or the like. Thus, they have found that the imidazodiazepine compound of the present invention has a PAM action on a dopamine DI receptor, and thereby completed the present invention. The imidazodiazepine compound of the present invention has a PAM action on a dopamine DI receptor, and is expected to be an agent for preventing and/or treating cognitive impairment, schizophrenia negative symptom, CIAS, Parkinson's disease, Alzheimer's disease, Huntington's disease, depression, ADHD, drug dependency, or the like. [Selected Figure] Nil
Bibliography:Application Number: MY2017PI704807