ANTIBODY CONSTRUCTS FOR FLT3 AND CD3

The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human FLT3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the...

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Bibliographic Details
Main Authors RAUM, Tobias, PENDZIALEK, Jochen, HOFFMANN, Patrick, BLUEMEL, Claudia, BOTT, Franziska, DAHLHOFF, Christoph, NAHRWOLD, Elisabeth
Format Patent
LanguageEnglish
Published 27.09.2022
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human FLT3 on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.
Bibliography:Application Number: MY2018PI700199