BISPECIFIC ANTIBODIES SPECIFIC FOR PD1 AND TIM3

The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity...

Full description

Saved in:
Bibliographic Details
Main Authors STEFAN SEEBER, VIKTOR LEVITSKI, CHRISTIAN KLEIN, VALERIA LIFKE, MARIO PERRO, GEORG FERTIG, JOERG THOMAS REGULA, TILMAN SCHLOTHAUER, PABLO UMA?A, LAURA CODARRI-DEAK, JENS FISCHER, ILDIKO WUENSCHE, ADRIAN ZWICK
Format Patent
LanguageEnglish
Published 06.08.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:The invention relates to bispecific antibodies comprising a first antigen-binding site that specifically binds to PD1 and a second antigen-binding site that specifically binds to TIM3, in particular to bispecific antibodies, wherein the bispecific antibody binds to TIM3 with a lower binding affinity when compared to the binding to PD1. The invention further relates to methods of producing these molecules and to methods of using the same.
Bibliography:Application Number: MY2018PI701289