CHIRAL SYNTHESIS OF N-{3,4-DIFLUORO-2-[(2-FLUORO-4-IODOPHENYL)AMINO]-6-METHOXYPHENYL}-1-[2,3-DIHYDROXY-PROPYL]CYCLOPROPANESULFONAMIDES

The present invention relates to a novel enantioselective method of preparing (5)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6- methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate com...

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Bibliographic Details
Main Authors FEY, PETER, MAYER, AGATHE, CHRISTINE
Format Patent
LanguageEnglish
Published 26.08.2021
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a novel enantioselective method of preparing (5)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-6- methoxyphenyl}-1-[2,3-dihydroxy-propyl]cyclopropanesulfonamide, to novel intermediate compounds, and to the use of said novel intermediate compounds for the preparation of said (5)- and (R)-enantiomers of N-{3,4-difluoro-2-[(2- fluoro-4-iodophenyl) amino] -6- methoxyphenyl}-1- [2,3 -dihydroxy-- propyl]cyclopropanesulfonamide :
Bibliography:Application Number: MY2013PI702269