PROCESS FOR THE ENZYMATIC SYNTHESIS OF (7S)-1-(3,4-DIMETHOXYBICYCLO[4.2.0]OCTA-1,3,5-TRIEN-7-YL) N-METHYL METHANAMINE, AND APPLICATION IN THE SYNTHESIS OF IVABRADINE AND SALTS THEREOF

Process for the enzymatic synthesis of the compound of formula (I), (7S)-l-(3,4-dimethoxy- bicyclo[4.2.0]octa-1,3,5-trien-7-yl) N-methyl methanarnine: and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.

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Bibliographic Details
Main Authors Sandrine PEDRAGOSA MOREAU, Francisco MORIS VARAS, Javier GONZALEZ SABIN, Francois LEFOULON
Format Patent
LanguageEnglish
Published 07.09.2020
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Summary:Process for the enzymatic synthesis of the compound of formula (I), (7S)-l-(3,4-dimethoxy- bicyclo[4.2.0]octa-1,3,5-trien-7-yl) N-methyl methanarnine: and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid.
Bibliography:Application Number: MY2013PI701065