MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80(B7-1)/PD-L1 PROTEIN/PROTEIN INTERACTIONS

The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases. Figure 1

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Main Authors SANGHVI, Nishith, MILLER, Michael Matthew, ZHU, Juliang, SUN, Li-Qiang, ALLEN, Martin Patrick, MULL. Eric, BOY, Kenneth M, YEUNG, Kap-Sun, LANGLEY, David R, TENNEY, Daniel J, BOWSHER, Michael S, GILLIS, Eric P, MAPELLI, Claudio, SCOLA, Paul Michael, REID, Patrick C, POIRIER, Maude A
Format Patent
LanguageEnglish
Published 21.08.2020
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Abstract The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases. Figure 1
AbstractList The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases. Figure 1
Author SANGHVI, Nishith
GILLIS, Eric P
POIRIER, Maude A
ALLEN, Martin Patrick
MULL. Eric
BOY, Kenneth M
TENNEY, Daniel J
BOWSHER, Michael S
MAPELLI, Claudio
YEUNG, Kap-Sun
MILLER, Michael Matthew
SUN, Li-Qiang
REID, Patrick C
SCOLA, Paul Michael
LANGLEY, David R
ZHU, Juliang
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– fullname: ALLEN, Martin Patrick
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– fullname: BOY, Kenneth M
– fullname: YEUNG, Kap-Sun
– fullname: LANGLEY, David R
– fullname: TENNEY, Daniel J
– fullname: BOWSHER, Michael S
– fullname: GILLIS, Eric P
– fullname: MAPELLI, Claudio
– fullname: SCOLA, Paul Michael
– fullname: REID, Patrick C
– fullname: POIRIER, Maude A
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Snippet The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the...
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Title MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80(B7-1)/PD-L1 PROTEIN/PROTEIN INTERACTIONS
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