MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80(B7-1)/PD-L1 PROTEIN/PROTEIN INTERACTIONS

The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases. Figure 1

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Main Authors SANGHVI, Nishith, MILLER, Michael Matthew, ZHU, Juliang, SUN, Li-Qiang, ALLEN, Martin Patrick, MULL. Eric, BOY, Kenneth M, YEUNG, Kap-Sun, LANGLEY, David R, TENNEY, Daniel J, BOWSHER, Michael S, GILLIS, Eric P, MAPELLI, Claudio, SCOLA, Paul Michael, REID, Patrick C, POIRIER, Maude A
Format Patent
LanguageEnglish
Published 21.08.2020
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Summary:The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases. Figure 1
Bibliography:Application Number: MY2015PI703242