DISPIROPYRROLIDINE DERIVATIVES

A novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1) having various substituents that inhibits int...

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Main Authors WAKABAYASHI, TAKANORI, YOSHIDA, KEISUKE, UOTO, KOUICHI, YOSHIDA, SHOKO, SUGIMOTO, YUUICHI, SETOGUCHI, MASAKI, TANIGUCHI, TORU, YAMAGUCHI, AKITAKE, MIYAZAKI, MASAKI
Format Patent
LanguageEnglish
Published 13.12.2019
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Summary:A novel compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1) having various substituents that inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
Bibliography:Application Number: MY2013PI03257