SUBSTITUTED BENZIMIDAZOLES AS KINASE INHIBITORS

New substituted benzimidazole compounds of formula (I), compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one ser...

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Main Authors RAMURTHY, SAVITHRI, SHAFER, CYNTHIA, SUBRAMANIAN, SHARADHA, PICK, TERESA E, AMIRI, PAYMAN, POON, DANIEL J, STUART, DARRIN, AIKAWA, MINA E, DOVE, JEFFREY H, MCBRIDE, CHRISTOPHER, LEVINE, BARRY HASKELL, RENHOWE, PAUL A
Format Patent
LanguageEnglish
Published 15.11.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:New substituted benzimidazole compounds of formula (I), compositions, and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activity of at least one serine/threonine kinase or receptor tyrosine kinase. The new compounds and compositions may be used either alone or in combination with at least one additional agent for the treatment of a serine/threonine kinase or receptor tyrosine mediated disorder, such as cancer.
Bibliography:Application Number: MY2008PI00095