IMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS

• Main Authors: NIELSEN, JACOB, MARIGO, MAURO, KEHLER, JAN, KILBURN, JOHN PAUL, LANGGARD, MORTEN
• Format: Patent
• Language: English
• Published: 15.09.2017
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

THIS INVENTION IS DIRECTED TO COMPOUNDS, WHICH ARE PDE10A ENZYME INHIBITORS. THE INVENTION PROVIDES A PHARMACEUTICAL COMPOSITION COMPRISING A THERAPEUTICALLY EFFECTIVE AMOUNT OF A COMPOUND OF THE INVENTION AND A PHARMACEUTICALLY ACCEPTABLE CARDER. THE PRESENT INVENTION ALSO PROVIDES PROCESSES FOR THE PREPARATION OF THE COMPOUNDS OF FORMULA I. THE PRESENT INVENTION FURTHER PROVIDES A METHOD OF TREATING A SUBJECT SUFFERING FROM A NEURODEGENERATIVE DISORDER COMPRISING ADMINISTERING TO THE SUBJECT A THERAPEUTICALLY EFFECTIVE AMOUNT OF A COMPOUND OF FORMULA I. THE PRESENT INVENTION ALSO PROVIDES A METHOD OF TREATING A SUBJECT SUFFERING FROM A DRUG ADDICTION COMPRISING ADMINISTERING TO THE SUBJECT A THERAPEUTICALLY EFFECTIVE AMOUNT OF A COMPOUND OF FORMULA I. THE PRESENT INVENTION FURTHER PROVIDES A METHOD OF TREATING A SUBJECT SUFFERING FROM A PSYCHIATRIC DISORDER COMPRISING ADMINISTERING TO THE SUBJECT A THERAPEUTICALLY EFFECTIVE AMOUNT OF A COMPOUND OF FORMULA I.