MACROCYCLES AS FACTOR XIA INHIBITORS

THE PRESENT INVENTION PROVIDES COMPOUNDS OF FORMULA (I): OR A STEREOISOMER, A TAUTOMER, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, WHEREIN ALL THE VARIABLES ARE AS DEFINED HEREIN. THESE COMPOUNDS ARE SELECTIVE FACTOR XLA INHIBITORS OR DUAL INHIBITORS OF FXLA AND PLASMA KALLIKREIN. THIS INVENTION...

Full description

Saved in:
Bibliographic Details
Main Authors FANG, TIANAN, CORTE, JAMES R, ROSSI, KAREN A, JEON, YOON, QUAN, MIMI L, HU, ZILUN, PINTO, DONALD J.P, DECICCO, CARL P, WANG, YUFENG, YANG, WU, SMALLHEER, JOANNE M
Format Patent
LanguageEnglish
Published 31.07.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:THE PRESENT INVENTION PROVIDES COMPOUNDS OF FORMULA (I): OR A STEREOISOMER, A TAUTOMER, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, WHEREIN ALL THE VARIABLES ARE AS DEFINED HEREIN. THESE COMPOUNDS ARE SELECTIVE FACTOR XLA INHIBITORS OR DUAL INHIBITORS OF FXLA AND PLASMA KALLIKREIN. THIS INVENTION ALSO RELATES TO PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS AND METHODS OF TREATING THROMBOEMBOLIC AND/OR INFLAMMATORY DISORDERS USING THE SAME.
Bibliography:Application Number: MY2012PI03575