IMMUNOTHERAPEUTIC FORMULATIONS TO GENERATE AUTOANTIBODIES CAPABLE TO AVOID THE BINDING OF INTERLEUKIN-2 TO ITS RECEPTOR.THEIR USE IN THE TREATMENT OF CANCER

THE PRESENT INVENTION IS RELATED TO PHARMACEUTICAL COMPOSITIONS BASED ON VACCINES AND MONOCLONAL ANTIBODIES THAT NEUTRALIZE THE INTERLEUKIN-2, WHICH ARE USEFUL IN THE TREATMENT OF TUMORS. PARTICULARLY THE PRESENT INVENTION IS RELATED TO THERAPEUTIC FORMULATIONS ABLE TO INCREASE THE IMMUNOGENICITY OF...

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Main Authors LIVÁN BLADIMIR ALONSO SARDUY, ROLANDO PÉREZ RODRÍGUEZ, AGUSTÍN BIENVENIDO LAGE DÁVILA, JOSÉ ENRIQUE MONTERO CASIMIRO
Format Patent
LanguageEnglish
Published 31.05.2017
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:THE PRESENT INVENTION IS RELATED TO PHARMACEUTICAL COMPOSITIONS BASED ON VACCINES AND MONOCLONAL ANTIBODIES THAT NEUTRALIZE THE INTERLEUKIN-2, WHICH ARE USEFUL IN THE TREATMENT OF TUMORS. PARTICULARLY THE PRESENT INVENTION IS RELATED TO THERAPEUTIC FORMULATIONS ABLE TO INCREASE THE IMMUNOGENICITY OF THE IL-2 CONJUGATED TO THE CARRIER PROTEIN P64K FROM THE NEISSERIA MENINGIFIDIS IN MONTANIDE ISA 51 ADJUVANT FOR THE INDUCTION OF IL-2 NEUTRALIZING AUTOANTIBODIES AND THE EFFECTIVE METHODS FOR THE TREATMENT OF TUMORS, INCLUDING BREAST CANCER. FURTHERMORE, THE PRESENT INVENTION IS RELATED TO THERAPEUTIC COMBINATION OF THE IL-2 BASED VACCINE WITH OTHER CANCER VACCINES BASED ON SPECIFIC TUMOR ANTIGENS OR TUMOR GROWTH FACTORS, AS WELL AS CHEMOTHERAPEUTICS AGENTS OR RADIOTHERAPY OF STANDARD USE FOR CANCER TREATMENT.
Bibliography:Application Number: MY2005PI05353