SERUM AMYLOID P DERIVATIVES AND THEIR PREPARATION AND USE

ONE ASPECT OF THE PRESENT INVENTION RELATES TO THE SURPRISING DISCOVERY THAT MODIFICATION OF A GLYCAN STRUCTURE ON A HUMAN SAP POLYPEPTIDE CAN INCREASE THE BIOLOGICAL ACTIVITY OF THE SAP POLYPEPTIDE RELATIVE TO A CORRESPONDING SAMPLE OF WILD-TYPE SAP ISOLATED FROM HUMAN SERUM. THE DISCLOSURE PROVIDE...

Full description

Saved in:
Bibliographic Details
Main Authors CAIMI,RICHARD J, WILLETT, W.SCOTT
Format Patent
LanguageEnglish
Published 15.11.2016
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:ONE ASPECT OF THE PRESENT INVENTION RELATES TO THE SURPRISING DISCOVERY THAT MODIFICATION OF A GLYCAN STRUCTURE ON A HUMAN SAP POLYPEPTIDE CAN INCREASE THE BIOLOGICAL ACTIVITY OF THE SAP POLYPEPTIDE RELATIVE TO A CORRESPONDING SAMPLE OF WILD-TYPE SAP ISOLATED FROM HUMAN SERUM. THE DISCLOSURE PROVIDES BOTH VARIANT HUMAN SAP POLYPEPTIDES AND METHODS FOR MAKING THE SAME. IN PARTICULAR, THE PRESENT INVENTION PROVIDES METHODS AND COMPOSITIONS FOR IN VITRO AND IN VIVO ADDITION, DELETION, OR MODIFICATION OF SUGAR RESIDUES TO PRODUCE SAP POLYPEPTIDES, SUCH AS A HUMAN SAP POLYPEPTIDE, HAVING A DESIRED GLYCOSYLATION PATTERN.
Bibliography:Application Number: MY2011PI05861