PROCESS FOR ENANTIOSELECTIVE SYNTHESIS OF SINGLE ENANTIOMERS OF THIO-SUBSTITUTED ARYLMETHANESULFINYL DERIVATIVES BY ASYMMETRIC OXIDATION FIELD OF THE INVENTION

THE INVENTION RELATES TO A METHOD FOR PREPARING A SULPHOXIDE COMPOUND OF FORMULA (1) EITHER AS A SINGLE ENANTIOMER OR IN AN ENANTIOMERICALLY ENRICHED FORM, COMPRISING THE STEPS OF. A) CONTACTING A PRO-CHIRAL SULPHIDE OF FORMULA (11) WITH A METAL CHIRAL COMPLEX, A BASE AND AN OXIDIZING AGENT IN AN OR...

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Bibliographic Details
Main Authors LOUVET PHILIPPE, PRAT LAURENCE, NECKEBROCK OLIVIER, SCHWEIZER DOMINIQUE
Format Patent
LanguageEnglish
Published 15.07.2016
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:THE INVENTION RELATES TO A METHOD FOR PREPARING A SULPHOXIDE COMPOUND OF FORMULA (1) EITHER AS A SINGLE ENANTIOMER OR IN AN ENANTIOMERICALLY ENRICHED FORM, COMPRISING THE STEPS OF. A) CONTACTING A PRO-CHIRAL SULPHIDE OF FORMULA (11) WITH A METAL CHIRAL COMPLEX, A BASE AND AN OXIDIZING AGENT IN AN ORGANIC SOLVENT ; AND OPTIONALLY B) ISOLATING THE OBTAINED SULPHOXIDE OF FORMULA WHEREIN AR, Y, R1 ARE AS DEFINED IN CLAIM 1.
Bibliography:Application Number: MY2006PI01095