3-PHENYLPYRAZOLO[5,1-B]THIAZOLE COMPOUND

A COMPOUND REPRESENTED BY THE FOLLOWING FORMULA (I), OR SALT THEREOF EXHIBITS EXCELLENT CRF RECEPTOR ANTAGONISM, AND SUFFICIENT PHARMACOLOGICAL ACTIVITY, SAFETY AND PHARMACOKINETIC PROPERTIES AS A DRUG. WHEREIN R1 REPRESENTS THE FORMULA ?A11-A12; R2 REPRESENTS TETRAHYDROFURYLMETHYL, TETRAHYDROPYRANY...

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Main Authors YOSHINORI TAKAHASHI, KUNITOSHI TAKEDA, HISASHI SHIBATA, KOGYOKU SHIN, KODO SHIKATA, TARO TERAUCHI, AKIRO INOMATA, MINAKO HASHIZUME
Format Patent
LanguageEnglish
Published 31.10.2014
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:A COMPOUND REPRESENTED BY THE FOLLOWING FORMULA (I), OR SALT THEREOF EXHIBITS EXCELLENT CRF RECEPTOR ANTAGONISM, AND SUFFICIENT PHARMACOLOGICAL ACTIVITY, SAFETY AND PHARMACOKINETIC PROPERTIES AS A DRUG. WHEREIN R1 REPRESENTS THE FORMULA ?A11-A12; R2 REPRESENTS TETRAHYDROFURYLMETHYL, TETRAHYDROPYRANYLMETHYL OR TETRAHYDROPYRANYL; A11 REPRESENTS A SINGLE BOND, METHYLENE OR 1,2-ETHYLENE; A12 REPRESENTS C1-6 ALKYL, C3-6 CYCLOALKYL OR C3-6 CYCLOALKYL HAVING METHYL; R3 REPRESENTS METHOXY, CYANO, CYCLOBUTYLOXYMETHYL, METHOXYMETHYL OR ETHOXYMETHYL; AND R4 REPRESENTS METHOXY OR CHLORINE.
Bibliography:Application Number: MY2010PI04527