INDUSTRIAL METHOD FOR THE SYNTHESIS OF 17-ACETOXY-11-ß-[4-(DIMETHYLAMINO)-PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIEN-3,20-DIONE AND THE KEY INTERMEDIATES OF THE PROCESS

• Main Authors: TERDY, LASZLO, SANTA, CSABA, TUBA, ZOLTAN, MOLNAR, CSABA, VISKY, GYOERGY, MAHO, SANDOR, CSOERGEI, JANOS, HORVATH, ZOLTAN, BALOGH, GABOR, BODI, JOZSEF, ARANYI, ANTAL, SZELES, JANOS
• Format: Patent
• Language: English
• Published: 30.08.2013
• Subjects: CHEMISTRY; METALLURGY; ORGANIC CHEMISTRY; STEROIDS

THE PRESENT INVENTION RELATES TO A PROCESS FOR THE SYNTHESIS OF THE KNOWN 17-ACETOXY-11-?-[4-(DIMETHYL AMINO)-PHENYL]-21-METHOXY-19-NORPREGNA-4,9-DIEN-3,20-DIONE (FURTHER ON CDB-4124) OF FORMULA (I) FROM 3,3-[1 ,2-ETHANDIYL-BIS(OXY)]-OESTR-5(10),9(11)-DIEN-17-ONE OF FORMULA (II). COMPOUND CDB-4124 BELONGS TO THE GROUP OF ANTI-HORMONES. THE INVENTION ALSO RELATES TO NEW INTERMEDIATES OF 11?-[4-(DIMETHYLAMINO)-PHENYL]-3,3-[1,2-ETHANDIYL-BIS(OXY)]-5,17A-BIS-[TRIMETHYL-SILYL-(OXY)]-5A-OESTR-9-EN-17?-CARBONITRILE OF FORMULA (VII) AND11?-[4-(DIMETHYLAMINO)-PHENYL]-3,3-[1,2-ETHANDIYL-BIS(OXY)]-5,17?-BIS-[TRIMETHYL-SILYL-(OXY)]-5?-OESTR-9-EN-17?-CARBALDEHIDE OF FORMULA (VIII)