INHIBITORS OF SERINE PROTEASES, PARTICULARLY HCV NS3-NS4A PROTEASE

THE PRESENT INVENTION RELATES TO COMPOUNDS THAT INHIBIT SERINE PROTEASE ACTIVITY, PARTICULARLY THE ACTIVITY OF HEPATITIS C VIRUS NS3-NS4A PROTEASE. AS SUCH, THEY ACT BY INTERFERING WITH THE LIFE CYCLE OF THE HEPATITIS C VIRUS AND ARE ALSO USEFUL AS ANTIVIRAL AGENTS. THE INVENTION FURTHER RELATES TO...

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Bibliographic Details
Main Authors SHAWN D. BRITT, JOHN J. COURT, ROBERT B. PERNI, JOHN H. VAN DRIE, JANOS PITLIK
Format Patent
LanguageEnglish
Published 28.02.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:THE PRESENT INVENTION RELATES TO COMPOUNDS THAT INHIBIT SERINE PROTEASE ACTIVITY, PARTICULARLY THE ACTIVITY OF HEPATITIS C VIRUS NS3-NS4A PROTEASE. AS SUCH, THEY ACT BY INTERFERING WITH THE LIFE CYCLE OF THE HEPATITIS C VIRUS AND ARE ALSO USEFUL AS ANTIVIRAL AGENTS. THE INVENTION FURTHER RELATES TO COMPOSITIONS COMPRISING THESE COMPOUNDS EITHER FOR EX VIVO USE OR FOR ADMINISTRATION TO A PATIENT SUFFERING FROM HCV INFECTION. THE INVENTION ALSO RELATES TO METHODS OF TREATING AN HCV INFECTION IN A PATIENT BY ADMINISTERING A COMPOSITION COMPRISING A COMPOUND OF THIS INVENTION. THE INVENTION FURTHER RELATES TO PROCESSES FOR PREPARING THESE COMPOUNDS.
Bibliography:Application Number: MY2004PI03610