PROCESSES AND INTERMEDIATES FOR PREPARING ANTI-CANCER COMPOUNDS

• Main Authors: TIMOTHY NORRIS, RICHARD SHELTON LEHNER, DINOS PAUL SANTAFIANOS
• Format: Patent
• Language: English
• Published: 30.09.2008
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; AGRICULTURE; ANIMAL HUSBANDRY; APPARATUS THEREFOR; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES; CHEMISTRY; FERROUS OR NON-FERROUS ALLOYS; FISHING; FORESTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF; PRETREATMENT OF RAW MATERIALS; PRODUCTION AND REFINING OF METALS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING; TREATMENT OF ALLOYS OR NON-FERROUS METALS

THE PRESENT INVENTION RELATES TO METHODS AND INTERMEDIATES FOR PRPEARING COMPOUNDS OF THE FORMULA 1 AND THE PHARMACEUTICALLY ACCEPTABLE SALTS AND SOLVATES THEREOF, AS WELL AS STRUCTUALLY RELATED COMPOUNDS , WHEREIN R1, R2 AND R15 ARE AS DEFINED HEREIN. THE FOREGOING COMPOUNDS ARE USEFUL IN THE TREATMENT HYPERPROLIFERATIVE DISORDERS , SUCH AS CANCERS,IN MAMMALS.