STABLE POLYMORPH OF N-(3-ETHYNYLPHENYL)-6, 7-BIS (2-METHOXYETHOXY)-4- QUINAZOLINAMINE HYDROCHLORIDE, METHODS OF PRODUCTION, AND PHARMACEUTICAL USES THEREOF

THE PRESENT INVENTION RELATES TO THE STABLE POLYMORPH B FORM OF N-(3-ETHYNYLPHENYL)-6, 7-BIS (2-METHOXYETHOXY) -4-QUINAZOLINAMINE HYDROCHLORIDE, ITS PRODUCTION IN ESSENTIALLY PURE FORM, AND ITS USE. THE INVENTION ALSO RELATES TO THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE STABLE POLYMORPH B FORM...

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Main Authors TIMOTHY NORRIS, JEFFREY W. RAGGON, BARBARA A. FOSTER, KAREN J. FERRANTE, RICHARD D. CONNELL, JAMES D. MOYER, SHAMA M. KAJIJI, SANDRA L. SILBERMAN, MICHAEL J. MORIN
Format Patent
LanguageEnglish
Published 30.03.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SEPARATION
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TRANSPORTING
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Summary:THE PRESENT INVENTION RELATES TO THE STABLE POLYMORPH B FORM OF N-(3-ETHYNYLPHENYL)-6, 7-BIS (2-METHOXYETHOXY) -4-QUINAZOLINAMINE HYDROCHLORIDE, ITS PRODUCTION IN ESSENTIALLY PURE FORM, AND ITS USE. THE INVENTION ALSO RELATES TO THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE STABLE POLYMORPH B FORM OF N-(3-ETHYNYLPHENYL)-6, 7-BIS(2-METHOXYETHOXY) -4-QUINAZOLINAMINE AS HYDROCHLORIDE, AS WELL OTHER FORMS OF THE COMPOUND, AND TO METHODS OF TREATING HYPERPROLIFERATIVE DISORDERS, SUCH AS CANCER, BY ADMINISTERING THE COMPOUND.FIGURE 1.
Bibliography:Application Number: MY2000PI05272