VACCINE COMPOSITION

THE PRESENT INVENTION RELATES TO AN IMMUNO-PROTECTIVE AND NON-TOXIC GRAM-NEGATIVE BLEB VACCINE SUITABLE FOR PAEDIATRIC USE.EXAMPLES OF THE GRAM-NEGATIVE STRAINS FROM WHICH THE BLEBS ARE MADE ARE N.MENINGITIDIS,M.CATARRHALIS AND H.INFLUENZAE.THE BLEBS OF THE INVENTION ARE IMPROVED BY ONE OR MORE GENE...

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Main Authors GEORGES THIRY, JOELLE THONNARD, PIERRE VOET, YVES LOBET, PHILIPPE DENOEL, FRANCOIS-XAVIER JACQUES BERTHET, WILFRIED L J DALEMANS, JAN POOLMAN, CHRISTIANE FERON, GUY DEQUESNE
Format Patent
LanguageEnglish
Published 30.03.2007
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
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Summary:THE PRESENT INVENTION RELATES TO AN IMMUNO-PROTECTIVE AND NON-TOXIC GRAM-NEGATIVE BLEB VACCINE SUITABLE FOR PAEDIATRIC USE.EXAMPLES OF THE GRAM-NEGATIVE STRAINS FROM WHICH THE BLEBS ARE MADE ARE N.MENINGITIDIS,M.CATARRHALIS AND H.INFLUENZAE.THE BLEBS OF THE INVENTION ARE IMPROVED BY ONE OR MORE GENETIC CHANGES TO THE CHROMOSOME OF THE BACTERIUM,INCLUDING UP-REGULATION OF PROTECTIVE ANTIGENS, DOWN-REGULATION OF IMMUNODOMINANT NON-PROTECTIVE ANTIGENS,AND DETOXIFICATION OF THE LIPID A MOIETY OF LPS.
Bibliography:Application Number: MY2000PI03523