RESOLUTION OF 1-AZABICYCLO (2.2.2.) OCTON -3-AMINE, 2-(DIPHENYLMETHYL)-N- [[2-METHOXY-5-(1-MEHTYLETHYL) PHENYL]METHYL]

THIS INVENTION RELATES TO A PROCESS FOR RESOLVING 1-AZABICYCLO[2.2.2JOCTAN-3-AMINE, 2-(DIPHENYLMETHYL)-N-[[2-METHOXY-5-(1-METHYLETHYL)PHENYLJMETHYLJ COMPRISING REACTING 1-AZABICYCLO [2.2.2J OCTAN-3-AMINE, 2-( DIPHENYLMETHYL)-N-[[2-METHOXY-5-(1-METHYLETHYL)PHENYLJMETHYLJ WITH 1 R-(-)-1 O-CAMPHORSUTFO...

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Bibliographic Details
Main Authors DEREK L. TICKNER, MORGAN MELTZ
Format Patent
LanguageEnglish
Published 30.08.2003
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:THIS INVENTION RELATES TO A PROCESS FOR RESOLVING 1-AZABICYCLO[2.2.2JOCTAN-3-AMINE, 2-(DIPHENYLMETHYL)-N-[[2-METHOXY-5-(1-METHYLETHYL)PHENYLJMETHYLJ COMPRISING REACTING 1-AZABICYCLO [2.2.2J OCTAN-3-AMINE, 2-( DIPHENYLMETHYL)-N-[[2-METHOXY-5-(1-METHYLETHYL)PHENYLJMETHYLJ WITH 1 R-(-)-1 O-CAMPHORSUTFONIC ACID IN SOLVENT CAPABLE OF DISSOLVING BOTH OF THE FOREGOING REAGENTS, AND SELECTIVELY DISSOLVING THE CAMPHORSULFONIC ACID SALT OF THE CORRESPONDING (2R,3R) ENANTIOMER RELATIVE TO THE (25,35) ENANTIOMER, TO FORM THE CAMPHORSULFONIC ACID SALT OF (25, 35)-1-AZABICYCLO [2.2.2]OCTAN-3-AMINE, 2-(DIPHENYLMETHYL)-N-[[2-METHOXY-5-(1-METHYLETHYL)PHENYL]METHYL], AND THEN OPTIONALLY HYDROLYZING SUCH SALT TO OBTAIN THE FREE BASE OF THE (25, 35) ENANTIOMER.
Bibliography:Application Number: MY1996PI02939