BUTYLENE OXIDE-ETHYLENE OXIDE BLOCK COPOLYMER SURFACTANTS AS STABILIZER COATINGS FOR NANOPARTICLE COMPOSITIONS

THIS INVENTION PROVIDES A COMPOSITION COMPRISED OF NANOPARTICLES CONTAINING A THERAPEUTIC OR DIAGNOSTIC AGENT HAVING A NONIONIC POLYMERIC SURFACTANT AS A SURFACE MODIFIER ADSORBED ON THE SURFACE THEREOF, THE SURFACTANT BEING A BLOCK COPOLYMER OF ETHYLENE OXIDE AND BUTYLENE OXIDE AND A METHOD OF MAKI...

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Bibliographic Details
Main Author WONG, SUI MING
Format Patent
LanguageEnglish
Published 31.05.2001
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:THIS INVENTION PROVIDES A COMPOSITION COMPRISED OF NANOPARTICLES CONTAINING A THERAPEUTIC OR DIAGNOSTIC AGENT HAVING A NONIONIC POLYMERIC SURFACTANT AS A SURFACE MODIFIER ADSORBED ON THE SURFACE THEREOF, THE SURFACTANT BEING A BLOCK COPOLYMER OF ETHYLENE OXIDE AND BUTYLENE OXIDE AND A METHOD OF MAKING SUCH NANOPARTICLES. THE COMPOSITIONS EXHIBIT REDUCED MACROPHAGE UPTAKE AND IMPROVED TOXICOLOGICAL PROFILES AND FACILITATE PARTICLE SIZE REDUCTION SUCH THAT MILLING TIME CAN BE REDUCED AND/OR STERILE FILTRATION OF THE NANOPARTICLES CAN BE ACCOMPLISHED.
Bibliography:Application Number: MY1919PI951774