HETEROCYCLIC COMPOUNDS

• Main Authors: STUART DENNETT MILLS, BERNARD JOSEPH MCLOUGHLIN, RODNEY BRIAM HARGREAVES
• Format: Patent
• Language: English
• Published: 31.03.1995
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

THIS INVENTION CONCERNS NOVEL COMPOUNDS OF THE FORMULA 1: (FORMULA. 1)IN WHICH P IS A GROUP OF FORMULA II OR A GROUP OF FORMULA III; IS ALKYL, CYCLOALKYL, CYCLOALKYLALKYL, PHENYL OR PHENYLALKYL; R2 IS HYDROGEN, ALKYL, AMINO OR ALKYLAMINO; AND R3 AND R4 ARE INDEPENDENTLY HYDROGEN, ALKYL, PHENYL OR BENZYL; R6 IS ALKYL, AMINO OR ALKYLAMINO; C AND D ARE INDEPENDENTLY ETHYLENE OR TIRMETHYLENE; Z IS A DIRECT BOND BETWEEN C AND D, OR AN OXY, THIO CARBONYL, METHYLENE, ETHYLENEDIOXYMETHYLENE, ETHYLIDENE, OR ISPOROPYLIDENE LINK, OR Z IS A GROUP OF THE FORMULA = N.R5 AND R5 IS ALKYL, PHENYL OR BENZYL; R8 IS HYDROGEN, CYCLOALKYLALKYL, ALKYL, ALKENYL, ALKYNYL OR PHENYLALKYL; OR R8 IS ALKYLENE OR ALKENYLENE LINKED TO THE NITROGEN ATOM OF THE GROUP Q.A.N-, EITHER OF WHICH LINKING GROUPS MAY OPTIONALLY BEAR A ALKYL, PHENYL OR PHENYLALKYL SUBSTITUENT AND EITHER OF WHICH LINKING GROUPS THEREBY COMPLETES A RING INCLUDING TWO ADJACENT CARBON ATOMS OF RING Q, ANY CARBON ATOMS IN A AND THE ADJACENT NITROGEN ATOM OF THE GROUP -A.N-; A IS A DIRECT BOND TO THE GROUP -N(R8)- OR IS ALKYLENE; Q IS A PHENYL OR PYRIDYL MOIETY; Y IS A PHYSIOLOGICALLY ACCEPTABLE ANION; AND WHEREIN ANY ONE OR MOTE OF SAID PHENYL, BENZENE OR PYRIDYL MOIETIES MAY OPTIONALLY UNSUBSTITUTED OR BEAR ONE OR MORE SELECTED SUBSTITUENTS. THE INVENTION ALSO INCLUDES CERTAIN CLOSELY RELATED ANHYDO-BASE DERIVATIVES WHICH, LIKE THE COMPOUNDS OF FORMULA I POSSESS BENEFICIAL EFFECTS ON THE CARDIOVASCULAR SYSTEM (AND IN PARTICULAR BENEFICIAL EFFECTS MODULATED VIA THE SINO-ATRIAL NODE). ALSO INCLUDED ARE PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS OF FORMULA I (OR A RELATED ANHYDRO-BASE) AS ACTIVE INGRIDENT, AND PROCESSES FOR THE MANUFACTURE OF THE VARIUOS NOVEL COMPOUNDS.