CORNEAL NEURITOGENESIS PROMOTER CONTAINING PACAP AND ITS DERIVATIVE

• Main Authors: NAKAMURA, YOSHIKUNI, ONOUE, SATOMI, AZUMA, MITSUYOSHI, YABUTA, CHIHO, INOUE, YUTAKA, TAKAYAMA, YOSHIKO
• Format: Patent
• Language: English; Spanish
• Published: 28.03.2007
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

It is intended to provide a corneal neuritogenesis promoter containing PACAP, a PACAP derivative or a pharmaceutically acceptable salt thereof, in particular, a corneal neuritogenesis promoter aiming at improving corneal perception, treating dry eye and treating corneal epithelial injury due to an effect of promoting corneal neuritogenesis. This corneal neuritogenesis promoter is useful as a drug for ameliorating reduction in corneal perception following corneal surgeries such as laser keratonomy (LASIK) and corneal grafting or cataract surgery, reduction in corneal perception accompanying corneal neurodegeneration and dry eye symptom and corneal epithelial injury accompanying such reduction in corneal perception. Moreover, it is useful as a drug for ameliorating dry eye symptom, reduction in corneal perception and corneal epithelial injury in patients with dry eye, and a drug for ameliorating corneal epithelial injury and dry eye symptom and reduction in corneal perception accompanying therewith. La presente invencion describe un agente para promover la neuritogenesis corneal que contiene PACAP, un derivado de PACAP o una sal del mismo farmaceuticamente aceptable, en particular, un agente para promover la neuritogenesis corneal indicado en el mejoramiento de la sensibilidad corneal, tratamiento de ojo seco y tratamiento de la lesion epitelial corneal debido a un efecto promotor de la neuritogenesis corneal; este agente para promover la neuritogenesis corneal es empleado como un farmaco para aliviar la reduccion en la sensibilidad corneal despues de las cirugias corneales, tales como queratonomia laser (LASIK) e injerto corneal o cirugia por cataratas, reduccion en la sensibilidad corneal que acompana la neurodegeneracion corneal y sintoma de ojo seco y lesion epitelial corneal que acompana tal reduccion en la sensibilidad corneal; sin embargo, es util como un farmaco para aliviar el sintoma del ojo seco, reduccion en la sensibilidad corneal y lesion epitelial corneal en pacientes con ojo seco, y un farmaco para aliviar la lesion corneal y sintoma de ojo seco y reduccion en la sensibilidad corneal que acompana a estos.